This course will introduce the student to contemporary Systems Biology focused on mammalian cells, their constituents and their functions. Biology is moving from molecular to modular. As our knowledge of our genome and gene expression deepens and we develop lists of molecules (proteins, lipids, ions) involved in cellular processes, we need to understand how these molecules interact with each other to form modules that act as discrete functional systems. These systems underlie core subcellular processes such as signal transduction, transcription, motility and electrical excitability. In turn these processes come together to exhibit cellular behaviors such as secretion, proliferation and action potentials. What are the properties of such subcellular and cellular systems? What are the mechanisms by which emergent behaviors of systems arise? What types of experiments inform systems-level thinking? Why do we need computation and simulations to understand these systems?
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Great course! The only change i would ask for: after the test, could you let us see the correct response to the questions we got wrong? Thanks!
A fantastic introductory course. One should really treat this as an overview that needs to be followed by further study.
It's a challenging subject. Don't expect to walk away from the course with a complete grasp of systems biology. However, this course is a fantastic place to start.
Great introduction and overview. Exams are especially well thought out.