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学生对 加州大学圣地亚哥分校 提供的 基因、蛋白质和基因组的对比(生物信息学 Ⅲ) 的评价和反馈

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Once we have sequenced genomes in the previous course, we would like to compare them to determine how species have evolved and what makes them different. In the first half of the course, we will compare two short biological sequences, such as genes (i.e., short sequences of DNA) or proteins. We will encounter a powerful algorithmic tool called dynamic programming that will help us determine the number of mutations that have separated the two genes/proteins. In the second half of the course, we will "zoom out" to compare entire genomes, where we see large scale mutations called genome rearrangements, seismic events that have heaved around large blocks of DNA over millions of years of evolution. Looking at the human and mouse genomes, we will ask ourselves: just as earthquakes are much more likely to occur along fault lines, are there locations in our genome that are "fragile" and more susceptible to be broken as part of genome rearrangements? We will see how combinatorial algorithms will help us answer this question. Finally, you will learn how to apply popular bioinformatics software tools to solve problems in sequence alignment, including BLAST....



Aug 18, 2016

A very well taught course that gives you the ins and outs of sequence comparision and introduces chromosme rearrangement analysis in a succint manner. This was


Dec 24, 2016

Take your time, this course is harder than the others. Very worth it though, learned a lot and it was a lot of fun!


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